Rodning C B, Wilson I D, Erlandsen S L
Lancet. 1976 May 8;1(7967):984-7. doi: 10.1016/s0140-6736(76)91860-2.
Human duodenal, jejunal, and ileal samples obtained at necropsy and by peroral and surgical biopsy, were studied by light microscopy using the unlabelled antibody enzyme method for imunocytochemical staining of lysozyme and immunoglobulins. Paneth cells contained IgA and IgG, but not IgD IgE, or IgM. Staining intensity indicated that IgA and IgG were present in amounts greater than in other epithelial cells. There was pronounced variation in the immunoglobulin content of Paneth cells. Rat Paneth cell containing IgA and lysozyme and are capable of the phagocytosis and degradation of microorganisms. These observations suggest that human Paneth cells may have similar functional capabilities.
通过尸检、经口活检和手术活检获取的人类十二指肠、空肠和回肠样本，采用未标记抗体酶法进行光镜检查，以对溶菌酶和免疫球蛋白进行免疫细胞化学染色。潘氏细胞含有IgA和IgG，但不含IgD、IgE或IgM。染色强度表明，IgA和IgG的含量高于其他上皮细胞。潘氏细胞的免疫球蛋白含量存在显著差异。大鼠潘氏细胞含有IgA和溶菌酶，能够吞噬和降解微生物。这些观察结果表明，人类潘氏细胞可能具有类似的功能能力。
