Deavers D R, Musacchia X J, Meininger G A
J Appl Physiol Respir Environ Exerc Physiol. 1980 Oct;49(4):576-82. doi: 10.1152/jappl.1980.49.4.576.
Water and electrolyte excretion was investigated in antiorthostatic hypokinetic and orthostatic hypokinetic and control rats in metabolic cages. Significant (t test, P < 0.05), diuresis, natriuresis, and kaliuresis occurred in the antiorthostatic hypokinetic subjects but did not occur in either the orthostatic hypokinetic or controls. Recovery from antiorthostatic hypokinesia was characterized by retention of water, sodium, and potassium. Patterns of changes in body weight and food and water orthostatic hypokinetic rats and thus could not account for the differences in renal handling of water and electrolytes. Also, differences in ingestion of food and water in controls could not account for differences in excretion of water and electrolytes between these and antiorthostatic hypokinetic rats. It was concluded that the antiorthostatic position was responsible for the diuresis and natriuresis and that the antiorthostatic hypokinetic rat appears to be a good model for the study of water and electrolyte excretion during conditions such as bed rest, water immersion, and exposure to weightlessness.
在代谢笼中对反立位低动力、立位低动力和对照大鼠的水和电解质排泄进行了研究。反立位低动力组出现了显著的（t检验，P < 0.05）利尿、利钠和利钾现象，但立位低动力组和对照组均未出现。反立位低动力恢复的特征是水、钠和钾的潴留。立位低动力大鼠的体重、食物和水的变化模式与反立位低动力大鼠不同，因此无法解释肾脏对水和电解质处理的差异。此外，对照组食物和水摄入的差异也无法解释这些大鼠与反立位低动力大鼠之间水和电解质排泄的差异。得出的结论是，反立位姿势是利尿和利钠的原因，反立位低动力大鼠似乎是研究卧床休息、水浸和失重等情况下水和电解质排泄的良好模型。
