Wang C, Paulsen C A, Hopper B R, Rebar R W, Yen S S
J Clin Endocrinol Metab. 1980 Dec;51(6):1269-73. doi: 10.1210/jcem-51-6-1269.
The responses of circulating levels of androgens, estrogens, and their C-21 biosynthetic precursors to a 6-h constant infusion of human Lh (hLH; 2000 IU) were studied in four males with hypogonadotropic hypogonadism (HH) and compared with those in normal male controls. Although similar levels of circulating LH were achieved, the initial and secondary increases in testosterone were significantly greater in the hypogonadotropic subjects than in the normal controls. In contrast, the responses of estradiol, estrone, 17 alpha-hydroxyprogesterone, and 17 alpha-hydroxypregnenolone to exogenous hLH were significantly lower in HH than in normal controls. The data demonstrate a different pattern of testicular steroidogenic responsiveness after pharmacological doses of hLH, with increased concentrations of circulating testosterone in subjects with HH compared to a disproportionate increase in estrogen and progestin levels in normal men.
在四名低促性腺激素性性腺功能减退（HH）男性中，研究了雄激素、雌激素及其C-21生物合成前体的循环水平对持续6小时输注人促黄体生成素（hLH；2000 IU）的反应，并与正常男性对照进行比较。尽管两组达到了相似的循环促黄体生成素水平，但低促性腺激素受试者睾酮的初始和继发性升高显著高于正常对照。相比之下，HH患者中雌二醇、雌酮、17α-羟孕酮和17α-羟孕烯醇酮对外源性hLH的反应显著低于正常对照。数据表明，给予药理剂量的hLH后，睾丸类固醇生成反应模式不同，HH患者循环睾酮浓度增加，而正常男性雌激素和孕激素水平增加不成比例。
