Lightman S L, Langdon N, Forsling M L
J Clin Endocrinol Metab. 1980 Dec;51(6):1447-9. doi: 10.1210/jcem-51-6-1447.
Experiments were performed to study the effects of opioids on both the plasma arginine vasopressin and renal responses to hypertonic saline. Neither the opiate antagonist naloxone nor the enkephalin agonist DAMME [D-Ala2, MePhe4, Met (0)-ol)enkephalin] altered the vasopressin response to the same hypertonic stimulus, although DAMME increased free water clearance. In man, opioids do not seem to be important mediators of the vasopressin response to osmolar change.
进行了实验以研究阿片类药物对血浆精氨酸加压素以及肾脏对高渗盐水反应的影响。阿片受体拮抗剂纳洛酮和脑啡肽激动剂DAMME [D-丙氨酸2，甲硫苯丙氨酸4，甲硫氨酸（0）-脑啡肽]均未改变对相同高渗刺激的加压素反应，尽管DAMME增加了自由水清除率。在人类中，阿片类药物似乎并非渗透压变化时加压素反应的重要介质。
