el-Sebae A H
J Environ Sci Health B. 1980;15(6):689-721. doi: 10.1080/03601238009372215.
Future biochemical challenges in toxicological research are discussed. The developed resistance of many insect pests to various commonly used insecticides is considered to be an extremely important problem. The need to develop new insecticides which are both environmentally safe and negatively cross-resistant with present insecticides is considered. The effectiveness of some pesticides can also be increased by the use of synergists. Synergists compete with the active substance at the detoxification sites and thereby reduce the effectiveness of the detoxification process. The effects of isomers, impurities, and metabolism products on the toxicity of various pesticides are presented. Finally, the need to further elucidate the mechanisms of action and selectivity of various pesticides is discussed.
本文讨论了毒理学研究中未来的生化挑战。许多害虫对各种常用杀虫剂产生抗性被认为是一个极其重要的问题。人们认为有必要开发对环境安全且与现有杀虫剂无负交叉抗性的新型杀虫剂。使用增效剂也可以提高一些农药的效力。增效剂在解毒位点与活性物质竞争，从而降低解毒过程的效力。介绍了异构体、杂质和代谢产物对各种农药毒性的影响。最后，讨论了进一步阐明各种农药作用机制和选择性的必要性。
