成年大鼠肝细胞单层原代培养物中胰岛素受体的下调。
Down regulation of insulin receptors in primary cultures of adult rat hepatocytes in monolayer.
作者信息
Blackard W G, Guzelian P S, Small M E
出版信息
Endocrinology. 1978 Aug;103(2):548-53. doi: 10.1210/endo-103-2-548.
PMID:744100
Abstract
Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration of insulin in the medium in order to evoke the down regulation phenomenon.
摘要
在单层培养的成年大鼠肝实质细胞原代培养物中，已证实在生理浓度（10⁻⁹ M）下胰岛素会下调胰岛素受体数量。然而，由于胰岛素在该培养系统中会迅速降解，所以需要特别努力来维持培养基中胰岛素的浓度，以引发下调现象。
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