血压水平的遗传模式。
The mode of inheritance of blood pressure levels.
作者信息
Rona R, Beresford S A
出版信息
J Epidemiol Community Health. 1980 Sep;34(3):168-73. doi: 10.1136/jech.34.3.168.
In a sample of 465 families living in a suburb of north-west London the systolic and diastolic blood pressure consistently showed a greater correlation for sib/sib (0.16 to 0.28) than for parent/offspring (0.07 to 0.18); this pattern is consistent with the hypothesis of a dominance component in the inheritance of blood pressure assuming there is no difference in the interaction between environment and genes in people of different ages. This assumption was examined by studying the sib/sib correlation according to the age gap between sibs; for diastolic blood pressure this remained almost the same but for systolic blood pressure the correlation tended to diminish as the age gap increased. A dominance component in the inheritance of blood pressure levels could explain the sort of results we have found in this study. However, we cannot ignore the fact that similar results could be obtained if the contribution of the environment within the same generation of relatives differs from that of the environment shared by all relatives.
在伦敦西北部一个郊区的465个家庭样本中，收缩压和舒张压在同胞之间的相关性（0.16至0.28）始终高于亲子之间（0.07至0.18）；这种模式与血压遗传中存在显性成分的假设一致，前提是不同年龄人群的环境与基因之间的相互作用没有差异。通过根据同胞之间的年龄差距研究同胞之间的相关性来检验这一假设；对于舒张压，这种相关性几乎保持不变，但对于收缩压，随着年龄差距的增加，相关性趋于减弱。血压水平遗传中的显性成分可以解释我们在本研究中发现的这类结果。然而，我们不能忽视这样一个事实，即如果同一代亲属内部环境的贡献与所有亲属共享的环境的贡献不同，也可能获得类似的结果。
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