Oraedu A C, Voaden M J, Marshall J
J Neurochem. 1980 Dec;35(6):1361-9. doi: 10.1111/j.1471-4159.1980.tb09010.x.
Endogenous amino acids were measured in retinas of rats exposed for up to 48 h to fluorescent light. Typical light damage was seen in photoreceptor cells after 30 h exposure to a maximum luminance of 1544 scotopic lux; and, from this time, taurine levels were significantly reduced. In contrast, the concentrations of other amino acids increased. After 18 h exposure to light, GABA, glycine, glutamate, and aspartate levels were raised in the photoreceptor cells, and GABA, glutamate, and glutamine levels in the inner retina. When 'exposed' animals were returned to their normal environment for 72 h, photoreceptor degeneration progressed and taurine concentrations were further reduced: the results suggest that the loss was from damaged photoreceptor cells. At this time the concentrations of the other amino acids measured had, in general, returned to normal.
对暴露于荧光灯下长达48小时的大鼠视网膜中的内源性氨基酸进行了测量。暴露于最大亮度为1544暗视觉勒克斯的光照30小时后，在光感受器细胞中可见典型的光损伤；从此时起，牛磺酸水平显著降低。相比之下，其他氨基酸的浓度升高。光照18小时后，光感受器细胞中的GABA、甘氨酸、谷氨酸和天冬氨酸水平升高，内视网膜中的GABA、谷氨酸和谷氨酰胺水平升高。当“暴露”的动物回到正常环境72小时后，光感受器变性进展，牛磺酸浓度进一步降低：结果表明损失来自受损的光感受器细胞。此时，所测量的其他氨基酸浓度总体上已恢复正常。
