Wessells N K, Letourneau P C, Nuttall R P, Ludueña-Anderson M, Geiduschek J M
J Neurocytol. 1980 Oct;9(5):647-64. doi: 10.1007/BF01205031.
The motility of growth cones of embryonic peripheral neurons is not inhibited by contact with the surfaces of neurites or of non-neuronal cells. Rather, growth cones and microspikes adhere to other cell surfaces and often respond with forward movement and elongation in contact with other cells, as they do on adhesive surfaces in vitro. Furthermore, non-neuronal cells do not display contact inhibition when they contact growth cones or neurites. If anything, surface motility and ruffling is stimulated by contact with a neuronal cell surface and some non-neuronal cells prefer to migrate along neurites rather than on the surface of the culture dish. These observations on the contact behaviour of cells from peripheral nerve ganglia imply that the surfaces of embryonic neurons differ from those of non-neuronal cells in that the neuronal surfaces do no elicit the typical contact inhibition response.
胚胎外周神经元生长锥的运动性不会因与神经突表面或非神经元细胞表面接触而受到抑制。相反，生长锥和微刺会附着在其他细胞表面，并且在与其他细胞接触时常常会像在体外黏附表面上一样做出向前运动和伸长的反应。此外，非神经元细胞在与生长锥或神经突接触时不会表现出接触抑制。如果有什么不同的话，与神经元细胞表面接触会刺激表面运动性和边缘波动，并且一些非神经元细胞更喜欢沿着神经突迁移，而不是在培养皿表面迁移。这些关于外周神经节细胞接触行为的观察结果表明，胚胎神经元的表面与非神经元细胞的表面不同，在于神经元表面不会引发典型的接触抑制反应。
