Egnatz D G, Ott M G, Townsend J C, Olson R D, Johns D B
J Occup Med. 1980 Nov;22(11):727-32.
The agriculturally important nematocide 1,2-dibromo-3-chloropropane (DBCP) has been implicated as a cause of human male sterility. A survey at the Michigan Division of The Dow Chemical Company included measurements of semen samples, testicular size, and serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone in 232 chemical workers with past potential exposures to DBCP and in 97 nonexposed comparison employees. Potentially exposed groups showed significantly higher, although not abnormal, mean levels of FSH and LH. In the subgroup with the highest potential exposure ending subsequent to 1972, greater duration of exposure correlated with lower sperm count, higher FSH level, and smaller testicular volume. Mean values for this latter time-divided subgroup were not abnormal. The findings are consistent with a testicular effect of DBCP and also with reversibility of that effect over time.
具有农业重要性的杀线虫剂1,2 - 二溴 - 3 - 氯丙烷（DBCP）被认为是导致人类男性不育的一个原因。陶氏化学公司密歇根分部的一项调查对232名过去可能接触过DBCP的化学工人以及97名未接触过DBCP的对照员工进行了精液样本、睾丸大小以及血清促卵泡激素（FSH）、促黄体生成素（LH）和睾酮的检测。潜在接触组的FSH和LH平均水平显著更高，尽管未出现异常。在1972年之后结束的潜在接触程度最高的亚组中，接触时间越长，精子数量越低、FSH水平越高且睾丸体积越小。后一个按时间划分的亚组的平均值并无异常。这些发现与DBCP对睾丸的影响一致，也与该影响随时间的可逆性一致。
