Whorton M D
West J Med. 1982 Dec;137(6):521-4.
Studies assessing reproductive function among male workers were rare in the United States before the discovery of sterility and infertility in 1977 among employees of a pesticide formulating plant in central California. Subsequently, the etiologic agent, dibromochloropropane (DBCP), has been shown in numerous studies of humans and animals to produce similar effects. While studies on the influence of workplace exposures to various chemicals on reproductive function have proliferated during the past five years, no other single agent has approached the dramatic effects exhibited by DBCP. Other agents that have been evaluated and have shown some adverse effects are reviewed critically. Studies of spontaneous abortion or congenital abnormalities in children of wives of men exposed to anesthetic gases and DBCP indicate that pregnancy outcome, as well as infertility and sterility, is an important outcome measure.
1977年加利福尼亚州中部一家农药配制厂的员工中发现不育和不孕问题之前，美国评估男性工人生殖功能的研究很少。随后，在众多对人类和动物的研究中已表明，病因剂二溴氯丙烷（DBCP）会产生类似影响。尽管在过去五年中，关于工作场所接触各种化学物质对生殖功能影响的研究激增，但没有其他单一制剂能达到DBCP所表现出的显著效果。对已评估并显示出一些不良影响的其他制剂进行了严格审查。对接触麻醉气体和DBCP的男性的妻子所生子女的自然流产或先天性异常的研究表明，妊娠结局以及不育和不孕是重要的结局指标。
