Beskid M, Kowalik J, Maciejczyk W
Exp Pathol (Jena). 1978;15(6):355-60. doi: 10.1016/s0014-4908(78)80043-x.
The object of the study was the liver of newborn rats. Specimens were taken from the 2nd to the 8th hour after birth. Tissue material was obtained from control animals and the newborns whose mothers had been ethanol fed throughout gestation period. 40% ethanol was administered in doses of 8.0 g/kg weight, by gastric tube. In the newborn liver ethanol ingestion had led to significant accumulation of lipids, a strong acid phosphatase reaction and to a drop in succinic dehydrogenase activity. Histochemically, the intensity of alcohol dehydrogenase activity did not show any difference when the ethanol treated newborn liver was compared with controls. Ultrastructurally, the changes in the liver cells were expressed by a disappearance of the rough endoplasmic reticulum elements. Mitochondria were often swollen and distorted.
该研究的对象是新生大鼠的肝脏。标本取自出生后第2至8小时。组织材料取自对照动物以及其母亲在整个妊娠期都喂食乙醇的新生大鼠。通过胃管以8.0克/千克体重的剂量给予40%乙醇。在新生大鼠肝脏中，摄入乙醇导致脂质显著蓄积、酸性磷酸酶反应增强以及琥珀酸脱氢酶活性下降。组织化学分析表明，将经乙醇处理的新生大鼠肝脏与对照相比，乙醇脱氢酶活性强度未显示出任何差异。超微结构上，肝细胞的变化表现为粗面内质网成分消失。线粒体常常肿胀变形。
