Beskid M
Exp Pathol (Jena). 1979;17(2):65-70. doi: 10.1016/s0014-4908(79)80028-9.
The object of the study was the cerebral cortex of newborn rat. Tissue samples for examination were collected from the 2nd to the 8th hour after birth. Experimental material was the tissue of control animals and newborns whose mothers had been treated with both ethanol and pyrazole throughout gestation, and also with either ethanol or pyrazole alone. Ethanol and pyrazole were administered by gastric tube, ethanol at doses of 8.0 g/kg body weight, pyrazole at doses of 36 mg/kg body weight. The results indicate that ethanol ingested by the mother during gestation inhibits cell maturation in the cerebral cortex, whereas the combined administration of ethanol and pyrazole produces a highly toxic action. Its morphological exponent are symptoms which support the diagnosis of encephalitis congenita symptomatica toxica.
本研究的对象是新生大鼠的大脑皮层。用于检查的组织样本在出生后第2至8小时采集。实验材料包括对照动物以及其母亲在整个妊娠期均接受乙醇和吡唑处理、或仅接受乙醇或吡唑处理的新生动物的组织。乙醇和吡唑通过胃管给药，乙醇剂量为8.0克/千克体重，吡唑剂量为36毫克/千克体重。结果表明，母亲在妊娠期摄入乙醇会抑制大脑皮层中的细胞成熟，而乙醇和吡唑联合给药会产生高度毒性作用。其形态学指标是支持先天性症状性中毒性脑炎诊断的症状。
