Cignarella G, Grella G, Loriga M, Curzu M M, Schiatti G
Farmaco Sci. 1978 Nov;33(11):866-74.
The antihypertensive 5-methyl-6-p.cyanophenyl-4,5-dihydro-3(2H)-pyridazinone has been embodied in a rigid framework corresponding to a 4,4a-dihydro-5H-indeno[1,2-c]-3-pyridazinonic structure (II). The resulting 7-cyano derivative (IIc) was found to be devoid of antihypertensive activity. However this compound, as well as other members having structure (II), exhibited antiinflammatory properties.
抗高血压药物5-甲基-6-对氰基苯基-4,5-二氢-3(2H)-哒嗪酮已被构建在一个与4,4a-二氢-5H-茚并[1,2-c]-3-哒嗪酮结构（II）相对应的刚性骨架中。所得到的7-氰基衍生物（IIc）被发现没有抗高血压活性。然而，该化合物以及其他具有结构（II）的成员表现出抗炎特性。
