[源自6-芳基哒嗪酮类抗高血压药物的刚性结构的意外抗炎活性。II. 5H-茚并(1,2-c)哒嗪和5H-茚并(1,2-c)哒嗪-3-酮的合成与活性]
[Unexpected anti-inflammatory activity of rigid structures derived from 6-arylpyridazinone antihypertensive agents. II. Synthesis and activity of 5H-indeno(1,2-c)pyridazine and 5H-indeno(1,2-c)pyridazin-3-one].
作者信息
Loriga M, Aimé Pinna G, Cignarella G, Schiatti G
出版信息
Farmaco Sci. 1979 Jan;34(1):72-80.
PMID:553822
Abstract
The synthesis of 5H-indeno[1,2-c]pyridazine (V) and of some derivatives were reported. The compounds synthesised generally retained the antiinflammatory activity exhibited by the 4,4a-dihydro derivatives of this class, previously tested. Moreover (V) showed analgesic and antipyretic properties higher than those of acetylsalicylic acid.
摘要
报道了5H-茚并[1,2-c]哒嗪（V）及其一些衍生物的合成。所合成的化合物通常保留了此前测试过的该类4,4a-二氢衍生物所具有的抗炎活性。此外，（V）显示出比乙酰水杨酸更高的镇痛和解热特性。
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[Unexpected anti-inflammatory activity of rigid structures derived from 6-arylpyridazinone antihypertensive agents. II. Synthesis and activity of 5H-indeno(1,2-c)pyridazine and 5H-indeno(1,2-c)pyridazin-3-one].[源自6-芳基哒嗪酮类抗高血压药物的刚性结构的意外抗炎活性。II. 5H-茚并(1,2-c)哒嗪和5H-茚并(1,2-c)哒嗪-3-酮的合成与活性]
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