Shekelle R B, Shryock A M, Paul O, Lepper M, Stamler J, Liu S, Raynor W J
N Engl J Med. 1981 Jan 8;304(2):65-70. doi: 10.1056/NEJM198101083040201.
Over twenty years ago, we evaluated diet, serum cholesterol, and other variables in 1900 middle-aged men and repeated the evaluation one year later. No therapeutic suggestions were made. Vital status was determined at the 20th anniversary of the initial examination. Scores summarizing each participant's dietary intake of cholesterol, saturated fatty acids, and polyunsaturated fatty acids were calculated according to the formulas of Keys and Hegsted and their co-workers. The two scores were highly correlated, and results were similar for both: there was a positive association between diet score and serum cholesterol concentration at the initial examination, a positive association between change in diet score and change in serum cholesterol concentration from the initial to the second examination, and a positive association prospectively between mean base-line diet score and the 19-year risk of death from coronary heart disease. These associations persisted after adjustment for potentially confounding factors. The results support the conclusion that lipid composition of the diet affects serum cholesterol concentration and risk of coronary death in middle-aged American men.
二十多年前，我们对1900名中年男性的饮食、血清胆固醇及其他变量进行了评估，并在一年后重复了该评估。未给出任何治疗建议。在初次检查的20周年时确定了生命状态。根据Keys、Hegsted及其同事的公式计算了总结每位参与者胆固醇、饱和脂肪酸和多不饱和脂肪酸饮食摄入量的分数。这两个分数高度相关，且两者结果相似：初次检查时饮食分数与血清胆固醇浓度呈正相关，从初次检查到第二次检查期间饮食分数的变化与血清胆固醇浓度的变化呈正相关，前瞻性地看，平均基线饮食分数与冠心病19年死亡风险呈正相关。在对潜在混杂因素进行调整后，这些关联依然存在。结果支持这样的结论：美国中年男性的饮食脂质成分会影响血清胆固醇浓度和冠状动脉死亡风险。
