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Evolutionary constraints in the mechanism of flavin catalysis.

作者信息

Visser C M

出版信息

Naturwissenschaften. 1980 Nov;67(11):549-55. doi: 10.1007/BF00450664.

DOI:10.1007/BF00450664
PMID:7442813
Abstract

Analysis of the possible evolution of flavin catalysis in succinate dehydrogenase suggests as the ultimate state an active site that bears one or more acid functions and uses the enediol form of the substrate rather than the carbanion as a nucleophile. In the case of flavoenzyme catalyzed oxidation of fatty acylCoA, alpha-amino acids and alpha-hydroxy acids evolution to a similar mechanism seems to be blocked.

摘要

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引用本文的文献

1
Evolutionary roots of catalysis by nicotinamide and flavins in C-H oxidoreductases and in photosynthesis.烟酰胺和黄素在碳氢氧化还原酶及光合作用中催化作用的进化根源。
Orig Life. 1982 Jun;12(2):165-79. doi: 10.1007/BF00927143.

本文引用的文献

1
Chemical achievement and hope for the future.化学成就与未来展望。
Am Sci. 1948 Jan;36(1):51-8.
2
Classification of methanogenic bacteria by 16S ribosomal RNA characterization.通过16S核糖体RNA特征对产甲烷菌进行分类。
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ELECTRONIC EFFECTS AND L-AMINO-ACID OXIDASE SPECIFICITY.
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Mitochondrial monoamine oxidase. II. Action of various inhibitors for the bovine kidney enzyme. Catalytic mechanism.
J Biol Chem. 1968 Oct 25;243(20):5234-43.
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Model studies on flavin-dependent oxidoreduction.
Vitam Horm. 1970;28:467-87. doi: 10.1016/s0083-6729(08)60907-3.
6
Studies on the mechanism of action of D-amino acid oxidase. Evidence for removal of substrate -hydrogen as a proton.D-氨基酸氧化酶作用机制的研究。关于以质子形式去除底物氢的证据。
J Biol Chem. 1971 Nov 25;246(22):6855-66.
7
The reduction of flavins by borohydride: 3,4-dihydroflavin. Struction, absorption and luminescence.硼氢化物对黄素的还原作用：3,4-二氢黄素。结构、吸收与发光
Eur J Biochem. 1969 Jun;9(3):392-401. doi: 10.1111/j.1432-1033.1969.tb00621.x.
8
Studies on the mechanism of action of the flavoenzyme lactate oxidase. Oxidation and elimination with beta-chlorolactate.黄素酶乳酸氧化酶作用机制的研究。β-氯乳酸的氧化与消除
J Biol Chem. 1973 Oct 25;248(20):7049-54.
9
Studies on the elimination reaction of D-amino acid oxidase with -amino- -chlorobutyrate. Further evidence for abstraction of substrate -hydrogen as a proton.
J Biol Chem. 1973 Mar 25;248(6):1946-55.
10
Mechanistic studies on the rat kidney flavoenzyme L-alpha-hydroxy acid oxidase.大鼠肾脏黄素酶L-α-羟酸氧化酶的机制研究。
Biochemistry. 1975 Jul 29;14(15):3482-9. doi: 10.1021/bi00686a030.