Kubo M, Osada M, Konno S
Natl Inst Anim Health Q (Tokyo). 1980 Summer;20(2):53-9.
The sulfur granules of actinomycosis and actinobacillosis were studied histologically and ultrastructurally. The sulfur granule of actinomycosis was large, and oval or horsehoe-shaped. In it, there were a number of gram-positive, filamentous or short rod-like hyphae beneath clubs. Ultrastructurally, the center of the sulfur granule was composed of a cluster of hyphae, and the periphery was surrounded by clubs arranged radially. The clubs were made of electron-dense fine granules and had a degenerated hypha at the center. These granules varied in amount from small to large. As for the host reaction, neutrophil infiltration appeared first around the sulfur granule. Then epithelioid cells proliferated and phagocytized hyphae. Finally, proliferating fibroblasts enclosed them and formed tiny granulomas. The sulfur granule of actinobacillosis was small and lobulated. In it, a number of gram-negative, short rod-like bacteria were present beneath clubs. Ultrastructurally, the center of the sulfur granule contained intact or degenerated bacteria, and the periphery was composed of radially projecting clubs. These clubs were made of electron-dense amorphous material, in which several layers of tubular structures surrounded the bacterium conentrically. The host reaction was almost the same as that of actinomycosis. The proliferation of fibroblasts was prominent. There was a strong tendency for these cells to form many tiny granulomas.
对放线菌病和放线杆菌病的硫黄颗粒进行了组织学和超微结构研究。放线菌病的硫黄颗粒较大，呈椭圆形或马蹄形。其中，在棍棒状结构下方有许多革兰氏阳性、丝状或短杆状菌丝。超微结构上，硫黄颗粒的中心由一簇菌丝组成，周边被呈放射状排列的棍棒状结构包围。棍棒状结构由电子致密的细颗粒组成，中心有一根退化的菌丝。这些颗粒数量不等，大小不一。关于宿主反应，首先在硫黄颗粒周围出现中性粒细胞浸润。然后上皮样细胞增殖并吞噬菌丝。最后，增殖的成纤维细胞将它们包裹起来，形成微小肉芽肿。放线杆菌病的硫黄颗粒较小，呈分叶状。其中，在棍棒状结构下方有许多革兰氏阴性、短杆状细菌。超微结构上，硫黄颗粒的中心含有完整或退化的细菌，周边由呈放射状突出的棍棒状结构组成。这些棍棒状结构由电子致密的无定形物质组成，其中几层管状结构同心地围绕着细菌。宿主反应与放线菌病几乎相同。成纤维细胞的增殖很明显。这些细胞有强烈的形成许多微小肉芽肿的倾向。
