Friedrich H, Hänsel-Friedrich G
Neurochirurgia (Stuttg). 1980 Nov;23(6):235-8. doi: 10.1055/s-2008-1053889.
Chloramphenicol was given to four neurosurgical patients intravenously. Serum and cerebrospinal fluid (CSF) concentrations were determined with High-pressure-Liquid-Chromatography (HPLC). A comparison with results reported in the literature shows that in patients without meningitis there is markedly lower concentration of chloramphenicol in the CSF than expected, i.e. it penetrates the "blood-brain" barrier much less easily.
