Kühnen E, Pfeifer G, Frenkel C
Institut für Medizinische Mikrobiologie und Immunologie, Universitätsklinik Bonn.
Infection. 1987 Nov-Dec;15(6):422-4. doi: 10.1007/BF01647220.
Serum and cerebrospinal fluid (CSF) concentrations of fosfomycin were evaluated in 45 patients. Mean serum concentration was 260.1 mg/l at 15 min postinfusion in 35 patients receiving a 5 g bolus dose, and 440 mg/l in five patients receiving a 10 g bolus dose. Mean distribution volume was 18.5 l (5 g dose), the total clearance was 118.8 ml/min, half-life was nearly 2 h, and the determined AUC were 420.95 mg/l.h (5 g dose) and 423.57 mg/l.h (10 g dose). The average peaks at 360 min in CSF reached 11.6 mg/l (5 g dose) and 17.7 mg/l (10 g dose). The CSF/serum ratio was 9.24% (5 g dose), and 13.81% (10 g dose). The CSF levels were not below 30 mg/l from the second day on in patients receiving 3 X 5 g fosfomycin per day. Meningeal inflammation increased the CSF concentrations from 30 mg/l at 6 h up to 150 mg/l at 120 h in the saturation phase, e. g., up to 300% more in comparison to non-inflamed meninges.
对45例患者的磷霉素血清和脑脊液（CSF）浓度进行了评估。35例接受5g静脉推注剂量的患者在输注后15分钟时的平均血清浓度为260.1mg/L，5例接受10g静脉推注剂量的患者为440mg/L。平均分布容积为18.5L（5g剂量），总清除率为118.8ml/min，半衰期约为2小时，测定的AUC分别为420.95mg/L·h（5g剂量）和423.57mg/L·h（10g剂量）。脑脊液在360分钟时的平均峰值在5g剂量组达到11.6mg/L，10g剂量组达到17.7mg/L。脑脊液/血清比值在5g剂量组为9.24%，10g剂量组为13.81%。每天接受3×5g磷霉素治疗的患者从第二天起脑脊液水平不低于30mg/L。在饱和期，脑膜炎症使脑脊液浓度从6小时时的30mg/L增加到120小时时的150mg/L，例如，与未发炎的脑膜相比增加了多达300%。
