Shenolikar I S, Tilak T B
Nutr Metab. 1980;24(3):199-208. doi: 10.1159/000176342.
Three groups, each of 9 adult male monkeys were maintained for about 18 months on diets containing mustard oil, either 5 or 10%; or 10% peanut oil, respectively. Histological examination of hearts of monkeys fed either 5 or 10% mustard oil diets did not reveal any abnormality attributable to mustard oil intake, such as vacuolation and fibrosis of myocardium. However, the oxygen consumption, RCR and ADP/O ratio, were significantly lower in the mitochondria isolated from monkeys receiving 10% mustard oil than those isolated from 10% peanut oil receiving monkeys, in the left ventricle but not in the right ventricle. Moreover, the oxygen consumption in the homogenates of left ventricles of monkeys receiving mustard oil, either 5 or 10%, was significantly lower as compared to that in 10% peanut oil controls. These data indicate that ingestion of mustard oil is associated with decreased oxidative capacity of heart mitochondria. They also suggest that the homogenates of the hearts of monkeys receiving mustard oil may contain a factor which further inhibits mitochondria oxidation.
将三组，每组9只成年雄性猴子，分别用含5%或10%芥子油或10%花生油的饲料喂养约18个月。对喂食5%或10%芥子油饲料的猴子心脏进行组织学检查，未发现任何可归因于摄入芥子油的异常情况，如心肌空泡化和纤维化。然而，从接受10%芥子油的猴子分离出的线粒体中，左心室的氧消耗、呼吸控制率（RCR）和ADP/O比值显著低于从接受10%花生油的猴子分离出的线粒体，而右心室则没有这种情况。此外，与10%花生油对照组相比，接受5%或10%芥子油的猴子左心室匀浆中的氧消耗显著降低。这些数据表明，摄入芥子油与心脏线粒体氧化能力下降有关。它们还表明，接受芥子油的猴子心脏匀浆可能含有一种进一步抑制线粒体氧化的因子。
