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[同基因供体血清和淋巴细胞注射诱发实验性肾间质性肾炎后雌性CBA小鼠及其子代的肾脏状态]

[State of the kidneys of female CBA mice and their progeny following administration of serum and lymphoid cells of syngeneic donors with experimental nephroso-nephritis].

作者信息

Averkina R F, Suchkova N I

出版信息

Ontogenez. 1980;11(4):378-85.

PMID:7443180
Abstract

The state of kidneys was examined in the mice--recipients of blood serum and lymphoid cells from syngeneic mice-donars with experimental nephrosonephritis. The state of kidneys was also analyzed in the progeny (newborn and 3 months old mice) of females-recipients. Injuries of kidneys were noted in the adult mice-recipients (under the influence of antikidney antibodies and lymphoid cells sensibilized to the kidney antigen) and in their progeny. A suggestion is put forward on the role of immune factors (humoral and cellular) in the "transmission" of nephropathic activity in the system mother--foetus.

摘要

对患有实验性肾间质性肾炎的同基因小鼠供体的血清和淋巴细胞受体小鼠的肾脏状态进行了检查。还对雌性受体的后代(新生和3个月大的小鼠)的肾脏状态进行了分析。在成年受体小鼠(在抗肾抗体和对肾抗原致敏的淋巴细胞的影响下)及其后代中发现了肾脏损伤。提出了关于免疫因子(体液和细胞)在母体-胎儿系统中肾病活性“传递”中的作用的建议。

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