Chertkova A I, Belianchikova N I, Bukhman V M
Biull Eksp Biol Med. 1982 Jun;93(6):90-2.
The growth of syngeneic hepatoma H-2-73 in adult (CBA x C57BL/6j) F1 mice leads to the development of leukemoid response that is manifested by leukocytosis, splenomegaly and a considerable increase in the content of lymphoid cells in the spleen. Meanwhile the newborn recipients of the tumor do not develop leukemoid response but manifest physiological changes in the hemopoietic tissue normally occurring within the first weeks after birth. The sensitized cells of the spleen of the adult tumor-bearing mice enhance tumor growth in the newborn recipients and inhibit it in the adult mice. Spleen cells of normal adult donors do not affect tumor growth in the newborn recipients. The data obtained suggest that the opposite effect of the transferred sensitized spleen cells from the adult animals on tumor growth in the newborn and adult mice is related to the age-associated features of the immune system of recipient mice.
同基因肝癌H-2-73在成年（CBA×C57BL/6j）F1小鼠体内生长会导致类白血病反应的发生，表现为白细胞增多、脾肿大以及脾脏中淋巴细胞含量显著增加。与此同时，新生肿瘤受体不会出现类白血病反应，而是表现出出生后最初几周内造血组织中正常发生的生理变化。成年荷瘤小鼠脾脏中的致敏细胞会促进新生受体中的肿瘤生长，并抑制成年小鼠中的肿瘤生长。正常成年供体的脾细胞不会影响新生受体中的肿瘤生长。所获得的数据表明，成年动物转移的致敏脾细胞对新生和成年小鼠肿瘤生长的相反作用与受体小鼠免疫系统的年龄相关特征有关。
