Valentic J P, Leopold I H, Dea F J
Ophthalmology. 1980 Aug;87(8):815-20. doi: 10.1016/s0161-6420(80)35157-9.
The concentration of salicylic acid in human tears has been measured by using reverse-phase, high-pressure liquid chromatography. Pharmacokinetic profiles in tears and in plasma have been obtained following oral administration of 650, 1300, and 1950 mg of aspirin in normal subjects. Salicylate excretion in tears is dose-dependent and is proportional to the plasma concentration. Tear and plasma salicylate levels for rheumatology patients on salicylates are also included.
已通过反相高效液相色谱法测定了人泪液中水杨酸的浓度。在正常受试者口服650、1300和1950毫克阿司匹林后，获得了泪液和血浆中的药代动力学曲线。泪液中水杨酸盐的排泄呈剂量依赖性，且与血浆浓度成正比。还纳入了服用水杨酸盐的风湿病患者的泪液和血浆水杨酸盐水平。
