Coles W H, Jaros P A
Br J Ophthalmol. 1984 Aug;68(8):549-52. doi: 10.1136/bjo.68.8.549.
We studied ocular surface pH in 161 subjects. The mean pH for 133 normal volunteers was 7 . 11, SD 1 . 5. We found that older women had a more alkaline pH than other subjects, that the pH shifted from acid to alkaline during the day, that one hour of eyelid closure caused an acid shift in pH, and that pH recovered to baseline values within 40 minutes after acid drop instillation. We explored the mechanism of pH regulation, and we believe that pH changes could affect contact lens toleration, drug effectiveness, and clinical signs in disease processes.
我们对161名受试者的眼表pH值进行了研究。133名正常志愿者的平均pH值为7.11，标准差为1.5。我们发现老年女性的pH值比其他受试者更偏碱性，pH值在白天从酸性转变为碱性，闭眼1小时会导致pH值向酸性转变，并且在滴入酸性滴眼液后40分钟内pH值恢复到基线值。我们探究了pH值调节的机制，并且我们认为pH值变化可能会影响隐形眼镜的耐受性、药物疗效以及疾病过程中的临床症状。
