De Crémoux H, Georges R, Battesti J P, Amouroux J, Bedicam J M, Letinier J Y, De Metz S, Daudon P
Nouv Presse Med. 1980 Nov 29;9(45):3445-7.
Diffuse interstitial pneumopathy was found to be associated with limited Sjögren's syndrome (i.e. without connective tissue involvement) in 5 women aged from 48 to 83 years. The respiratory symptoms (dyspnoea, unproductive cough and crepitations) appeared before the dry-eye-and-mouth syndrome was diagnosed in two patients and several years afterwards in three. Respiratory function studies showed a mixed restrictive and obstructive syndrome, perturbed Co transfer and increased total expiratory airways resistance. These changes reflected the underlying pathology, as revealed by bronchial and lung biopsies, which consisted of lymphocyte and plasmocyte infiltration and fibrosis of the interalveolar septa, peribronchial spaces and bronchial glands. Abnormal respiratory function tests in 5 other patients without any respiratory symptom suggest that subclinical and subradiological lesions of the lungs and bronchi are not uncommon in Sjögren's syndrome.
在5名年龄在48至83岁的女性中，发现弥漫性间质性肺病与局限性干燥综合征（即无结缔组织受累）有关。两名患者的呼吸道症状（呼吸困难、干咳和捻发音）出现在干眼口干综合征诊断之前，另外三名患者则在诊断数年后出现。呼吸功能研究显示为混合性限制性和阻塞性综合征、一氧化碳转运受损和总呼气气道阻力增加。支气管和肺活检显示，这些变化反映了潜在的病理情况，表现为淋巴细胞和浆细胞浸润以及肺泡间隔、支气管周围间隙和支气管腺体的纤维化。另外5名无任何呼吸道症状的患者呼吸功能测试异常，这表明在干燥综合征中，肺和支气管的亚临床和亚放射学病变并不少见。
