Mirkova E
Probl Khig. 1980;5:83-91.
The antenatal effect of a Altax in doses 100 and 10 mg/kg was studied on two experimental animal species - rats and mice. Testing data showed that the compound has embryotoxic and teratogenic activity in dosex 100 mg/kg. The effect depended upon the time when the toxic agent was administered in the course of embryogenesis. Embryotoxic effect was recorded only in rats, teratogenic - in both animal species, being more marked in mouse embryos. The intrauterine activity of Altax in rats was accompanied by induction of anomalous morphogenesis: hydrocephalus, intracerebral hematomas, disturbances in cranial bone ossification. The teratogenic action of the Altax in mice was characterized by the appearance of external malformations: exencephaly, hypognatism, edema and anomalies of the internal organs - microphthalmia and hydrocephalus. The periods of late organogenesis and fetal development in rats are critical for the embryotoxic action of Altax, whereas the preimplantation stages and early organogenesis are sensitive for its teratogenic activity. Altax in dose of 10 mg/kg has no embryotoxic effect.
研究了100毫克/千克和10毫克/千克剂量的阿尔塔克斯对大鼠和小鼠这两种实验动物的产前影响。测试数据表明，该化合物在100毫克/千克剂量时具有胚胎毒性和致畸活性。其影响取决于在胚胎发生过程中给予毒性剂的时间。仅在大鼠中记录到胚胎毒性作用，在两种动物中均记录到致畸作用，在小鼠胚胎中更为明显。阿尔塔克斯在大鼠中的宫内活性伴随着异常形态发生的诱导：脑积水、脑内血肿、颅骨骨化紊乱。阿尔塔克斯在小鼠中的致畸作用表现为外部畸形的出现：无脑畸形、下颌发育不全、水肿和内部器官异常——小眼症和脑积水。大鼠的晚期器官发生期和胎儿发育期对阿尔塔克斯的胚胎毒性作用至关重要，而植入前阶段和早期器官发生期对其致畸活性敏感。10毫克/千克剂量的阿尔塔克斯没有胚胎毒性作用。
