Mühlbauer H, Hardt W
Pharmakopsychiatr Neuropsychopharmakol. 1980 Jul;13(4):213-7. doi: 10.1055/s-2007-1019633.
The prolactin (hPRL) level in the serum of 17 patients (10 females, 7 males) with primary depression (manic-depressive disease) was determined before and after prophylactic treatment with lithium salts. All patients were free of acute psychotic-depressive symptomes. However, 9 of 17 patients received moderate doses of additional antidepressive medication continuously for 4 weeks. No significant changes of the serum hPRL were observed in the group as a whole, the lithium serum levels being within the normal therapeutic range. The mean hPRL level in patients with concomitant antidepressive medication was significantly higher as compared to the "only lithium" group, but never exceeded the normal range in both groups. Considering similar results of other authors, it is suggested that lithium does not influence the hPRL serum level, at least if no special methods of hPRL stimulation are used. However, with regard to recent communications suggesting that besides dopaminergic influences also serotonergic mechanisms play an important part in hPRL regulation, it is held that the prolactin response in lithium-treated patients warrants further investigations using serotonergic stimulation methods.
测定了17例原发性抑郁症（躁郁症）患者（10例女性，7例男性）在使用锂盐进行预防性治疗前后血清中的催乳素（hPRL）水平。所有患者均无急性精神病性抑郁症状。然而，17例患者中有9例连续4周持续接受中等剂量的额外抗抑郁药物治疗。总体来看，该组血清hPRL未观察到显著变化，血清锂水平处于正常治疗范围内。与“仅使用锂盐”组相比，同时接受抗抑郁药物治疗的患者的平均hPRL水平显著更高，但两组均未超过正常范围。鉴于其他作者的类似结果，表明锂盐至少在未使用特殊hPRL刺激方法时不影响血清hPRL水平。然而，鉴于最近的报道表明，除了多巴胺能影响外，5-羟色胺能机制在hPRL调节中也起重要作用，认为对锂盐治疗患者的催乳素反应值得使用5-羟色胺能刺激方法进行进一步研究。
