Donehower R C
Recent Results Cancer Res. 1980;74:37-41. doi: 10.1007/978-3-642-81488-4_5.
Metabolism of methotrexate (MTX) to closely related analogues has been increasingly recognized in recent years. 7-Hydroxymethotrexate, 2,4-diamino-N10-methylpteroic acid, and methotrexate poly-gamma-glutamates have been established as products of metabolic conversion in man. The significance of the formation of these metabolites has not been firmly established. Certain of these compounds may play a role in the development of the renal failure syndrome associated with high-dose infusions, contribute to the chronic toxicity of MTX administration, and cross-react to a significant degree in radioimmunoassay methods for measurement of MTX concentrations.
近年来，甲氨蝶呤（MTX）代谢为密切相关类似物的现象越来越受到关注。7-羟基甲氨蝶呤、2,4-二氨基-N10-甲基蝶酸和甲氨蝶呤多聚γ-谷氨酸已被确认为人体代谢转化的产物。这些代谢产物形成的意义尚未完全明确。其中某些化合物可能在与高剂量输注相关的肾衰竭综合征的发生中起作用，导致甲氨蝶呤给药的慢性毒性，并在用于测量甲氨蝶呤浓度的放射免疫分析方法中产生显著的交叉反应。
