Kaul M N, Misra R C, Agarwal S K, Saha K
Scand J Immunol. 1980;11(6):623-8. doi: 10.1111/j.1365-3083.1980.tb00030.x.
Gut and serum immune responses were studied in twenty-two patients with bacteriologically proved typhoid fever at different stages of the illness and six volunteers after parenteral immunizations with heat-killed typhoid vaccine. Whereas the former group had some specific antibodies in their intestinal aspirates and significant specific antibody responses in their sera, the latter could only mount a serum antibody response. Moreover, the intestinal IgA levels in the patients remained significantly decreased throughout the whole course of the illness, but a rise of IgG and IgM was observed in their jejunal secretions. In contrast, the levels of all the three major classes of serum immunoglobulins IgG, IgM and IgA were raised in the patients, as opposed to the volunteers, in whom only IgG and IgM levels were increased. It was inferred that the subjects with deficit of intestinal IgA, and thus lacking protective mucosal barrier, are more prone to develop typhoid fever.
对22例经细菌学证实患伤寒热且处于疾病不同阶段的患者以及6名经皮下注射热灭活伤寒疫苗免疫的志愿者的肠道和血清免疫反应进行了研究。前一组患者的肠道吸出物中有一些特异性抗体，血清中有显著的特异性抗体反应，而后一组志愿者仅能产生血清抗体反应。此外，患者的肠道IgA水平在疾病全过程中持续显著降低，但在空肠分泌物中观察到IgG和IgM升高。相反，与志愿者相比，患者血清中所有三种主要免疫球蛋白IgG、IgM和IgA水平均升高，而志愿者仅IgG和IgM水平升高。据推断，肠道IgA缺乏从而缺乏保护性黏膜屏障的个体更容易患伤寒热。
