沙利度胺结构类似物对妊娠狒狒（黄狒狒）的非致畸性

Nonteratogenicity of a structural analog of thalidomide in pregnant baboons (Papio cynocephalus).

作者信息

Hendrickx A G, Helm F C

出版信息

Teratology. 1980 Oct;22(2):179-82. doi: 10.1002/tera.1420220206.

DOI:10.1002/tera.1420220206

Abstract

Teratologic evaluation of a mild tranquilizer being developed for human therapeutic use involved daily oral administration to 29 baboons (P. cynocephalus) during organogenesis according to three treatment regimens. In Phase I, 9 animals (3 groups of 3) received 2, 6, or 20 mg/kg CG 3033 per day for 28 consecutive days between 18 and 45 days gestation; in Phase II, 14 animals (7 groups of 2) were given 20 mg/kg CG 3033 for four consecutive days: 18-21, 22-25, 26-29, 30-33, 34-37, 38-41, or 42-45; and in Phase III, 6 animals (2 groups of 3) were administered 40 mg/kg daily between days 18-21 or 22-25 of gestation. No teratologic changes attributable to drug treatment were observed, and the abortion rate was within the range for controls.

摘要

对一种正在研发用于人类治疗的轻度镇静剂进行致畸学评估，在器官形成期，按照三种治疗方案对29只狒狒（豚尾狒狒）进行每日口服给药。在第一阶段，9只动物（3组，每组3只）在妊娠18至45天期间连续28天每天接受2、6或20mg/kg CG 3033；在第二阶段，14只动物（7组，每组2只）连续4天接受20mg/kg CG 3033：分别在妊娠18 - 21天、22 - 25天、26 - 29天、30 - 33天、34 - 37天、38 - 41天或42 - 45天；在第三阶段，6只动物（2组，每组3只）在妊娠18 - 21天或22 - 25天期间每天接受40mg/kg给药。未观察到归因于药物治疗的致畸变化，且流产率在对照范围内。