沙利度胺结构类似物的一种代谢产物在怀孕恒河猴中无致畸作用。
A metabolite of a structural analog of thalidomide lacks teratogenic effect in pregnant rhesus monkeys.
作者信息
Scott W J, Wilson J G, Helm F C
出版信息
Teratology. 1980 Oct;22(2):183-5. doi: 10.1002/tera.1420220207.
PMID:7444807
Abstract
A metabolite of CG 3033, a structural analog of thalidomide, was examined for teratogenic potential in rhesus monkeys. The metabolite EM 240 is produced in man by hydrolysis of the parent compound but the pathway is absent in nonhuman primates. Fifteen mg/kg administered orally throughout organogenesis to pregnant rhesus monkeys produced no evidence of embryotoxicity, including malformation.
摘要
沙利度胺的结构类似物CG 3033的一种代谢物，在恒河猴中进行了致畸潜力检测。代谢物EM 240在人体内由母体化合物水解产生，但在非人灵长类动物中不存在该途径。在整个器官形成期给怀孕的恒河猴口服15毫克/千克，未发现包括畸形在内的胚胎毒性证据。
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