Wolf E, Fine P E, Pritchard J, Watson B, Bradley D J, Festenstein H, Chacko C J, Stevens A
Tissue Antigens. 1980 May;15(5):436-46. doi: 10.1111/j.1399-0039.1980.tb00206.x.
Seventy-two families, selected for having at least two children affected with leprosy, were HLA typed for 57 A, B and C locus antigens recognized by the WHO Nomenclature Committee. In addition, 20 possible new "splits" were investigated. The distribution of A, B and C locus antigens in affected and unaffected family members was similar, irrespective of the type of leprosy in the family. Gene frequencies (derived by direct gene counting from 253 haplotypes), haplotype frequencies and delta values were calculated. There is evidence for heterogeneity of B5, B15, B17, Bw16 and Bw35 and for the existence of at least one A locus and one B locus antigen not previously detected. The value of the HLA system for detecting expaternal children in a highly inbred population and the effect of inbreeding on the HLA system is discussed.
选取了72个家庭，这些家庭中至少有两个孩子患麻风病，对其进行了HLA分型，检测了世界卫生组织命名委员会认可的57种A、B和C位点抗原。此外，还研究了20种可能的新“分裂”情况。无论家庭中麻风病的类型如何，受影响和未受影响家庭成员中A、B和C位点抗原的分布相似。计算了基因频率（通过对253个单倍型直接计数得出）、单倍型频率和δ值。有证据表明B5、B15、B17、Bw16和Bw35存在异质性，且存在至少一种先前未检测到的A位点和一种B位点抗原。讨论了HLA系统在高度近亲繁殖人群中检测非亲生子女的价值以及近亲繁殖对HLA系统的影响。
