Lawrence D N, Bodmer J G, Bodmer W F
Tissue Antigens. 1980 Aug;16(2):152-60. doi: 10.1111/j.1399-0039.1980.tb00596.x.
HLA typing was performed in 1978, using antisera recognizing specificities defined by the Seventh Workshop, on lymphocytes separated and frozen in the field during a 1976 expedition among Amazonian Ticuna Indians. Family segregation of HLA antigens was used to ascertain haplotypes of a sample of essentially unrelated reproductive-age adults. "Expaternal" haplotypes were also included in the total of 81 haplotypes used for calculating the A and B locus gene frequencies. Common A and B locus antigens among the Ticuna were Aw24, Aw31, A2, Bw39, B40, Bw35, and B15.1. Bw53 were also present. No A or B locus "blanks" were found. A slight degree of European admixture was apparent. Bw16-reactive cells from certain persons consistently failed to react with Oxford antisera capable of recognizing the Bw38 or Bw39 subspecificities. Cw1 and Cw3 were found in association with typical South American Indian haplotypes. The results of HLA typing of a large extended family with multiple cases of leprosy are depicted and compared to recently reported family studied of leprosy.
1978年进行了HLA分型，使用识别第七届研讨会定义的特异性的抗血清，对1976年在亚马逊提库纳印第安人中进行的一次探险期间在野外分离并冷冻的淋巴细胞进行检测。利用HLA抗原的家系分离来确定一组基本无亲缘关系的育龄成年人样本的单倍型。“外源性”单倍型也包含在用于计算A和B位点基因频率的总共81个单倍型中。提库纳人中常见的A和B位点抗原是Aw24、Aw31、A2、Bw39、B40、Bw35和B15.1。也存在Bw53。未发现A或B位点“空白”。有明显的轻微欧洲人血统混合迹象。某些人的Bw16反应性细胞始终不能与能够识别Bw38或Bw39亚特异性的牛津抗血清发生反应。发现Cw1和Cw3与典型的南美印第安人单倍型相关。描绘了一个有多个麻风病例的大型大家庭的HLA分型结果，并与最近报道的麻风病家系研究进行了比较。
