Tono-oka T, Nakayama M, Ohkawa M, Matsumoto S
Tohoku J Exp Med. 1980 Oct;132(2):173-8. doi: 10.1620/tjem.132.173.
Chemotactic responses of patients with a variety of diseases to two different types of chemotactic factors were analyzed. Granulocytes were obtained from the patients with childhood malignant diseases during chemotherapy, the patients with measles, the adult patients with recurrent aphthous stomatitis, and newborn infants. 22 out of all the 38 patients (58%) showed decreased chemotactic response to zymosan activated human serum (ZAS), whereas only 9 patients (24%) showed decreased response to Escherichia coli-derived chemotactic factor (bacterial chemotactic factor: BCF). Furthermore, only 6 out of 22 patients who showed decreased chemotaxis to ZAS showed decreased chemotaxis to BCF. Analogous results were also obtained with cord blood granulocytes. These facts suggest that various kinds of chemotactic factors activate granulocytes in different ways, and that the evaluation of chemotactic response in a patient should be made simultaneously using more than two different types of chemotactic factor.
分析了患有各种疾病的患者对两种不同类型趋化因子的趋化反应。粒细胞取自化疗期间的儿童恶性疾病患者、麻疹患者、复发性阿弗他口炎成年患者和新生儿。在所有38例患者中，22例（58%）对酵母聚糖激活的人血清（ZAS）的趋化反应降低，而只有9例患者（24%）对大肠杆菌衍生的趋化因子（细菌趋化因子：BCF）的反应降低。此外，在22例对ZAS趋化性降低的患者中，只有6例对BCF的趋化性降低。脐血粒细胞也得到了类似的结果。这些事实表明，各种趋化因子以不同方式激活粒细胞，并且对患者趋化反应的评估应同时使用两种以上不同类型的趋化因子。
