Isawa T, Teshima T, Hirano T, Shiraishi K, Matsuda T, Konno K
Tohoku J Exp Med. 1980 Oct;132(2):187-97. doi: 10.1620/tjem.132.187.
The effect of alveolar hypercapnia under a wide range of alveolar oxygen tensions was assessed in the right upper lobe of the normal dogs and the dogs with the reimplanted right lung. To induce alveolar hypercapnia by artificial ventilation of the right upper lobe, gas mixtures of differing oxygen fractions containing 10% or 20% CO2 were used as exchange gases for the right upper lobe. The concurrent alveolar hypercapnia had little superimposed effect on the regional vascular responses to a wide range of alveolar oxygen tensions in the normal and the reimplanted denervated lung lobe. Under an extreme alveolar hyperoxia, however, the concurrent alveolar hypercapnia somewhat suppressed regional hyperoxic vasodilation and/or recruitment of the pulmonary vascular beds, whereas in the reimplanted lung lobe it potentiated the hyperoxic pulmonary vascular response. The alveolar oxygen tension seems to be the main factor in the regulation of regional perfusion in the lungs.
在正常犬和右肺再植犬的右上叶评估了在广泛的肺泡氧分压范围内肺泡高碳酸血症的影响。为通过右上叶人工通气诱导肺泡高碳酸血症，含10%或20%二氧化碳的不同氧分数的气体混合物被用作右上叶的交换气体。同时存在的肺泡高碳酸血症对正常和再植去神经肺叶在广泛的肺泡氧分压范围内的局部血管反应几乎没有叠加影响。然而，在极端肺泡高氧情况下，同时存在的肺泡高碳酸血症在一定程度上抑制了局部高氧性血管舒张和/或肺血管床的募集，而在再植肺叶中它增强了高氧性肺血管反应。肺泡氧分压似乎是肺局部灌注调节中的主要因素。
