Isawa T, Teshima T, Hirano T, Ebina A, Shiraishi K, Konno K
Tohoku J Exp Med. 1981 May;134(1):59-69. doi: 10.1620/tjem.134.59.
Effects of isoproterenol and propranolol on regional pulmonary perfusion were assessed in the dog. In each experiment the right upper lobe was isolated in vivo by a balloon catheter and artificially ventilated with nitrogen, air or 60% oxygen in nitrogen before and after administration of the medicaments listed above. The rest of the lungs kept breathing air spontaneously. Following administration of isoproterenol regional pulmonary perfusion increased in the hypoxic right upper lobe induced by artificial ventilation with nitrogen, but the increase was not observed when isoproterenol was administered following pretreatment with propranolol. Administration of propranolol alone did not induce any change in regional pulmonary perfusion distribution. When artificial ventilation was done in the right upper lobe either with air or 60% oxygen in nitrogen, thus inducing regional less hypoxia or hyperoxia, no change in regional perfusion was observed with any of the medication. Thus isoproterenol reversed regional hypoxic pulmonary vasoconstriction, but its action was blocked by pretreatment with propranolol. Propranolol per se, however, showed no effect on pulmonary vascular responses to the different alveolar oxygen tensions.
评估了异丙肾上腺素和普萘洛尔对犬局部肺灌注的影响。在每个实验中，用球囊导管在体内分离右上叶，并在给予上述药物之前和之后用氮气、空气或含60%氧气的氮气进行人工通气。其余肺脏保持自主呼吸空气。给予异丙肾上腺素后，用氮气人工通气诱导的缺氧右上叶局部肺灌注增加，但在用普萘洛尔预处理后给予异丙肾上腺素时未观察到这种增加。单独给予普萘洛尔未引起局部肺灌注分布的任何变化。当右上叶用空气或含60%氧气的氮气进行人工通气，从而诱导局部轻度缺氧或高氧时，使用任何一种药物均未观察到局部灌注的变化。因此，异丙肾上腺素可逆转局部缺氧性肺血管收缩，但其作用被普萘洛尔预处理所阻断。然而，普萘洛尔本身对肺血管对不同肺泡氧张力的反应没有影响。
