Isawa T, Teshima T, Hirano T, Shiraishi K, Matsuda T, Konno K
Tohoku J Exp Med. 1979 Aug;128(4):345-53. doi: 10.1620/tjem.128.345.
Using ten normal dogs, the right upper lobe of the lung was isolated in vivo by a balloon catheter and was artificially ventilated with nitrogen, air, 60% oxygen in nitrogen, and 60% oxygen and 20% carbon dioxide in nitrogen, while the rest of the lungs maintained a spontaneous breathing of ambient air. Aminophylline did not show a vasodilating action under severe alveolar hypoxia (PAO2: ca. 40 mmHg); on the contrary, it seemed to potentiate hypoxic pulmonary vasoconstriction. When the regional alveolar oxygen tension became less hypoxic (PAO2: ca. 70 mmHg) or higher than that in the rest of the lungs which spontaneously breathed ambient air, aminophylline showed a definite vasodilating action. Aminophylline also showed a vasodilating action in alveolar hypercapnia in the presence of alveolar hyperoxia.
使用十只正常犬，通过球囊导管在体内分离出右上肺叶，并用氮气、空气、氮气中60%氧气以及氮气中60%氧气和20%二氧化碳进行人工通气，而其余肺组织维持对环境空气的自主呼吸。在严重肺泡低氧（动脉血氧分压：约40 mmHg）情况下，氨茶碱未表现出血管舒张作用；相反，它似乎增强了低氧性肺血管收缩。当局部肺泡氧张力低氧程度减轻（动脉血氧分压：约70 mmHg）或高于其余自主呼吸环境空气的肺组织时，氨茶碱表现出明确的血管舒张作用。在存在肺泡高氧的情况下，氨茶碱在肺泡高碳酸血症时也表现出血管舒张作用。
