Usubuchi I, Sato T, Kudo H
Tohoku J Exp Med. 1980 Oct;132(2):237-8. doi: 10.1620/tjem.132.237.
In the peritoneal cavity of the rat, Hirosaki sarcoma, as ascites tumor of the rat, acquired a resistance to the essentially effective dose of 100 microgram/kg of mitomycin C by means of the daily treatment with the ineffective dose of 10 or 1 microgram/kg of mitomycin C. It is considered that most of Hirosaki sarcoma cells may have gradually acquired a hereditary resistance to mitomycin C in the course of the contact with the drug.
