de Heer K, Werner B, Sauer H D, Klöppel G
Z Exp Chir. 1980 Apr;13(2):105-13.
The influence of cholestyramine and chenodeoxycholic acid on the induction of cirrhosis of the liver of the male Wistar strain rats was studied. The simultaneous dietary exposure of 1 g cholestyramine in 100 g diet prevented the development of cirrhosis induced by carbon tetrachloride. Whereas all the animals in the control group (CCl4-Exposure plus normal diet) developed cirrhosis, histologic examination showed cirrhosis in only 2 of 9 rats fed with diet containing cholestyramine. On the contrary, the exposure to chenodeoxycholic acid at a concentration of 1 g in 300 g diet potentiated the induction of cirrhosis. The experimental results support the clinical findings in which the administration of cholestyramine caused an improvement of liver function tests by cirrhosis.
研究了消胆胺和鹅去氧胆酸对雄性Wistar品系大鼠肝硬变诱导的影响。在100克饲料中同时给予1克消胆胺的饮食暴露可预防四氯化碳诱导的肝硬变发展。对照组（四氯化碳暴露加正常饮食）的所有动物均发生了肝硬变，而组织学检查显示，在喂食含消胆胺饲料的9只大鼠中，只有2只出现了肝硬变。相反，在300克饲料中给予浓度为1克的鹅去氧胆酸暴露会增强肝硬变的诱导。实验结果支持了临床研究结果，即消胆胺的给药可改善肝硬变患者的肝功能检查。
