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[对临床诊断已知和未知肝硬化死亡病例的比较形态学-统计学研究(作者译)]

[Comparative morphological-statistical investigations in deaths with clinically known and unknown hepatocirrhosis (author's transl)].

作者信息

Böhm E, Reissig G, Rosenstock J, Löbbecke F

出版信息

Zentralbl Allg Pathol. 1980;124(4):295-300.

PMID:7445795
Abstract

352 hepatocirrhosis cases were among the 7139 autopsy cases of the years 1964--1973. It could be ascertained statistically: Together with the increasing scarred liver transformation the number of oesophageal piles and ascites increased. The greater the scarred transformation and cirrhosis activity the higher was the number of hepatocirrhoses known at lifetime. An increase of spleen weight due to scarred liver transformation could not be proved. The expected correlation between degree of fibrosis and liver weight could not be confirmed. According to expectation, hepatocirrhosis cases known at lifetime caused death more frequently than cases with unknown hepatocirrhosis. We want to point out, however, that 13 cases of death may be directly attributed to clinically unknown hepatocirrhosis. The medically unknown hepatocirrhosis cases in one group were frequently still "young" hepatocirrhosis cases without ascites and oesophageal piles, or the clinical features of advanced hepatocirrhosis were masked by other severe diseases (e.g., anthracosilicosis of the lung).

摘要

在1964年至1973年的7139例尸检病例中,有352例肝硬化病例。经统计学分析可知:随着肝脏瘢痕化程度的增加,食管静脉曲张和腹水的数量也会增加。肝脏瘢痕化程度和肝硬化活动度越高,生前已知的肝硬化病例数就越多。未能证实肝脏瘢痕化会导致脾脏重量增加。纤维化程度与肝脏重量之间预期的相关性也未得到证实。不出所料,生前已知的肝硬化病例比未知肝硬化病例更常导致死亡。然而,我们要指出,有13例死亡可能直接归因于临床未知的肝硬化。一组中临床上未知的肝硬化病例往往仍是没有腹水和食管静脉曲张的“年轻”肝硬化病例,或者晚期肝硬化的临床特征被其他严重疾病(如肺煤矽肺)掩盖了。

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