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[乳酸杆菌和双歧杆菌制剂对受γ量子照射小鼠肠道微生物群的影响]

[Effect of lactobacillus and bifidobacteria preparations on the intestinal microflora of mice irradiated with gamma quanta].

作者信息

Korshunov V M, Kissina E V, Ikonnikova T B, Mal'tsev V N, Goncharova G I

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1980 Jun(6):47-54.

PMID:7445858
Abstract

Lactobacilli (strain B12G) and bifidobacteria (strain 75-41), administered orally in a dose of 5 x 10 cells to CBA mice on days 1, 3, 5 and 10 after irradiation with gamma quanta in a dose of 700 rad, restored the "eubiosis" of the intestinal tract, specifically suppressing opportunistic bacteria and facilitating the normalization of the quantitative and qualitative correlation between microbial associations constituting the obligatory intestinal flora. For one thing, the preparations of lactobacilli and bifidobacteria, used for treatment, restored the amount of lactobacilli in the intestinal tract of the irradiated animals to the level, characteristic of the intact animals; for another, these preparations prevented the dissemination of Escherichia, Proteus, Enterococcus in the small intestine and considerably decreased the amount of these microorganisms, as well as Clostridium, in the large intestine.

摘要

在以700拉德的γ量子剂量照射CBA小鼠后的第1、3、5和10天,口服给予剂量为5×10个细胞的乳酸杆菌(菌株B12G)和双歧杆菌(菌株75 - 41),可恢复肠道的“微生态平衡”,特别是抑制机会性细菌,并促进构成肠道固有菌群的微生物群落之间数量和质量相关性的正常化。一方面,用于治疗的乳酸杆菌和双歧杆菌制剂将受照射动物肠道内的乳酸杆菌数量恢复到未受照射动物的特征水平;另一方面,这些制剂可防止大肠杆菌、变形杆菌、肠球菌在小肠中的扩散,并显著减少这些微生物以及大肠中梭菌的数量。

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