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[辐照小鼠肠道微生物群变化的定量模式]

[Quantitative patterns in changes in the intestinal microflora of irradiated mice].

作者信息

Pinegin B V, Klemparskaia N N, Mal'tsev V N, Korshunov V M, Meretskov V V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1977 Jul(7):88-94.

PMID:899458
Abstract

Experiments were conducted on 3 groups of mice, gamma-irradiated in doses of 900, 600 and 300 r. Development of acute radiation sickness was accompained by development of intestinal dysbacteriosis. Characteristic was reduction of lactobacilli content and increase in the content of purulent microbes (E. coli, clostridia, Proteus, and enterococcus) in the large intestine, and an increase of enterococcus and Proteus content in the small intestine. Changes in the microbial count in the intestine, depending on the time lapse after the irradiation can be represented as a formula of linear dependence; this permitted to compare the rate of changes in the intestinal content of the microbes during the development of acute radiation sickness.

摘要

对三组小鼠进行了实验,分别用900、600和300伦琴的剂量进行γ射线照射。急性放射病的发展伴随着肠道菌群失调的发展。其特征是大肠中乳酸杆菌含量减少,化脓性微生物(大肠杆菌、梭菌、变形杆菌和肠球菌)含量增加,小肠中肠球菌和变形杆菌含量增加。肠道微生物数量的变化,取决于照射后的时间间隔,可用线性依赖公式表示;这使得能够比较急性放射病发展过程中肠道微生物含量的变化速率。

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