Koester G, Nilius B
Acta Biol Med Ger. 1980;39(5):513-23.
At spontaneously beating rabbit atria in vitro longtime pauses of contraction were produced by vagal stimulation. After finishing the stimulation at once contractions took place; the first of them was potentiated. During the vagal pauses various beat interval programs were realized. After removing the sinusoidal node the same programs were repeated by variation of drive interval length. Their effects were compared to the effects in vagal pauses. All these effects were simulated by a two stores three phases model. This model allows description of potentiation and staircase phenomena as well as inotropic vagal effect and inotropic vagal escape. It suggests a connection between this two kinds of phenomena.
在体外对自发搏动的兔心房进行迷走神经刺激,可产生长时间的收缩暂停。刺激结束后立即出现收缩,且首次收缩增强。在迷走神经暂停期间,实现了各种心动周期程序。摘除窦房结后,通过改变驱动间期长度重复相同的程序,并将其效应与迷走神经暂停时的效应进行比较。所有这些效应均由一个双储存三相模型模拟。该模型能够描述增强和阶梯现象,以及变力性迷走神经效应和变力性迷走神经脱逸。它提示了这两种现象之间的联系。