Zoneraich S, Zoneraich O, Rhee J J
Chest. 1977 Dec;72(6):748-51. doi: 10.1378/chest.72.6.748.
To examine left ventricular performance in diabetic patients without clinical evidence of cardiac involvement, systolic time intervals (pre-ejection period, left ventricular ejection time index and ratio of pre-ejection period to left ventricular ejection time) and echocardiographic measures (percentage changes in minor axis diameter, end-diastolic and end-systolic diameter, end- diastolic volume and end-systolic volumes, stroke volume and ejection fraction), were obtained. There were 89 diabetic patients and 93 control subjects evaluated for systolic time intervals, and 40 diabetic patients and 20 control subjects evaluated by echocardiogram. The diabetic group demonstrated significant (P less than 0.001) differences from the normal control group in each of the noninvasive measures of systolic time intervals. Pre-ejection period/left ventricular ejection time ration was increased by 25 percent and the pre-ejection period was increased by 12 percent in the diabetic patients. Among 40 diabetic patients studied by echocardiography, abnormal percentage change in minor axis diameter, (less than 30 percent) occurred in six individuals. Ejection fraction was decreased by 20 percent as compared to the control group, whereas end-diastolic pressure was not significantly different in the groups.
为了研究无心脏受累临床证据的糖尿病患者的左心室功能，获取了收缩期时间间期（射血前期、左心室射血时间指数以及射血前期与左心室射血时间之比）和超声心动图测量值（短轴直径、舒张末期和收缩末期直径、舒张末期容积和收缩末期容积、每搏输出量和射血分数的百分比变化）。对89例糖尿病患者和93例对照者进行了收缩期时间间期评估，对40例糖尿病患者和20例对照者进行了超声心动图评估。糖尿病组在收缩期时间间期的各项非侵入性测量指标上与正常对照组均存在显著差异（P小于0.001）。糖尿病患者的射血前期/左心室射血时间比值增加了25%，射血前期增加了12%。在接受超声心动图检查的40例糖尿病患者中，有6例短轴直径的异常百分比变化（小于30%）。与对照组相比，射血分数降低了20%，而两组间舒张末期压力无显著差异。
