Kanto J, Jalonen J, Laurikainen E, Nieminen V, Salo M
Acta Anaesthesiol Scand. 1980 Jun;24(3):178-80. doi: 10.1111/j.1399-6576.1980.tb01529.x.
After cranial subcutaneous injection of lidocaine 0.8-3.7 mg/kg+adrenaline (epinephrine) 1:200,000 in neurosurgical patients, fast drug absorption was found with peak plasma concentrations of 0.6-1 microgram/ml in 5-10 min. However, the concentrations remained above the lowest effective antiarrhythmic level of 0.6 microgram/ml for only about 10 min. In one patient, simultaneously administered intravenous lidocaine had an additive effect on those levels. Induced hypotension (sodium nitroprusside) during aneurysm operations decreased the arterial plasma level of lidocaine and was followed by a new peak after discontinuation. Thus the absorption of a drug during induced hypotension from subcutaneous tissue is often erratic.
在神经外科患者中，颅骨皮下注射0.8 - 3.7毫克/千克利多卡因+1:200,000肾上腺素后，发现药物吸收迅速，5 - 10分钟内血浆峰值浓度为0.6 - 1微克/毫升。然而，这些浓度仅在约10分钟内保持高于最低有效抗心律失常水平0.6微克/毫升。在一名患者中，同时静脉注射利多卡因对这些水平有相加作用。动脉瘤手术期间诱发的低血压（硝普钠）降低了利多卡因的动脉血浆水平，停药后出现新的峰值。因此，在诱发低血压期间，皮下组织中药物的吸收往往不稳定。
