Jordheim O, Hagen A G
Acta Obstet Gynecol Scand. 1980;59(4):315-7. doi: 10.3109/00016348009154086.
Premature rupture of the membrane is often followed by intrauterine infections. Antibiotic prophylaxis is recommended, but the effect has been debatable. Thirty pregnant women received pivampicillin 350 mg 4 times daily. The ampicillin levels in amniotic fluid and in the serum of the fetus and of the mother were determined and related to pivampicillin dose and time after administration. In the amniotic fluid the average concentration was 3.4 micrograms/ml, which is considered therapeutic. In maternal and fetal serum the ampicillin concentrations were low and took an almost parallel course. To obtain the same ratio between ampicillin serum levels and MIC (minimum inhibitory concentration) in the pregnant as in the non-pregnant subject, a double dosage should be used.
胎膜早破常伴有宫内感染。推荐使用抗生素进行预防，但效果一直存在争议。30名孕妇每日4次服用350毫克匹氨西林。测定了羊水以及胎儿和母亲血清中的氨苄西林水平，并将其与匹氨西林剂量及给药后的时间相关联。羊水中的平均浓度为3.4微克/毫升，这被认为具有治疗作用。在母体和胎儿血清中，氨苄西林浓度较低且变化趋势几乎平行。为了在孕妇中获得与非孕妇相同的氨苄西林血清水平与MIC（最低抑菌浓度）之比，应使用双倍剂量。
