Billewicz-Stankiewicz J, Gołabek W, Zaczkiewicz A
Acta Physiol Pol. 1980 May-Jun;31(3):305-15.
The experiments were carried out on male Wistar rats administering the tested catecholamines intraperitoneally. Water for diuresis induction and indomethacin solutions were introduced into the stomach through a tube. The hypophysis was destroyed totally with a needle inserted into an ear under stereotaxic controls. Lower adrenaline doses increased water diuresis, higher doses decreased it. Noradrenaline exerted only in antidiuretic effect. There was an analogy between the effects of these amines in diuresis and on adrenergic receptors. Hypophysectomy increased the antidiuretic action of adrenaline which could be due to absence of ACTH. Lower doses of indomethacin inhibited and higher doses enhanced the antidiuretic effect of amines. Intermediate doses were ineffective.
实验选用雄性Wistar大鼠，通过腹腔注射给予受试儿茶酚胺类药物。通过一根管子将诱导利尿的水和吲哚美辛溶液注入胃中。在立体定位控制下，用一根插入耳朵的针完全破坏垂体。较低剂量的肾上腺素增加尿量，较高剂量则减少尿量。去甲肾上腺素仅发挥抗利尿作用。这些胺类在利尿作用和对肾上腺素能受体的作用之间存在相似性。垂体切除增加了肾上腺素的抗利尿作用，这可能是由于促肾上腺皮质激素缺乏所致。较低剂量的吲哚美辛抑制胺类的抗利尿作用，较高剂量则增强其抗利尿作用。中等剂量无效。
