Moshang T, Holsclaw D S
Am J Dis Child. 1980 Dec;134(12):1139-42. doi: 10.1001/archpedi.1980.02130240023008.
Age, derived fat index (FI), and clinical score at the time of menarche were determined from records of 63 girls with cystic fibrosis (CF) and from 17 comparably aged but nonmenarchal girls with CF. The mean age of menarche in girls with CF was 14.5 years at a mean FI of 20.1% fat; thus, they were significantly older and had less fat than normal girls. Menarchal age was related to severity of illness. Amenorrheic girls with CF, mean age of 14 years, were significantly sicker and smaller. Gonadotropin and estradiol levels in 23 girls with CF were normal. The delay in menarche in CF appears to be closely related to severity of illness. Furthermore, although the relationship of puberty to body composition may or may not be coincidental, it is unlikely that puberty is initiated by a "critical body composition."
通过63名患有囊性纤维化（CF）女孩以及17名年龄相仿但未初潮的CF女孩的记录，确定了初潮时的年龄、脂肪指数（FI）和临床评分。CF女孩初潮的平均年龄为14.5岁，平均FI为20.1%脂肪；因此，她们比正常女孩年龄显著更大且脂肪更少。初潮年龄与疾病严重程度相关。CF闭经女孩的平均年龄为14岁，病情明显更严重且身材更小。23名CF女孩的促性腺激素和雌二醇水平正常。CF初潮延迟似乎与疾病严重程度密切相关。此外，尽管青春期与身体成分的关系可能是巧合，也可能不是，但青春期由“关键身体成分”启动的可能性不大。
