Tung K S, Alexander N J
Am J Pathol. 1980 Oct;101(1):17-29.
The immunopathologic findings in the testes and kidneys of 25 long-term vasectomized monkeys and of 13 age-matched control animals were compared. Antisperm antibody was found in serum samples from 60% of vasectomized monkeys and in no samples from control animals. Orchitis, aspermatogenesis, or both, resembling allergic orchitis, was noted in 92% of vasectomized animals and in 23% of controls. Epididymitis and epididymal granuloma occurred exclusively in the vasectomized animals (52%). By immunofluorescence, granular deposits of IgA, IgG, and/or C3 in the basal lamina of the ductuli efferentes and the caput epididymidis were detected in 45% of the control monkeys. In vasectomized animals, the incidence of immune deposits increased to 91%, and the deposits became more widespread. Although both vasectomized and control animals had IgM, IgG, or both, in the glomerular mesangial region, C3 was found in vasectomized monkeys only (29%). The results of this study indicate that monocytic infiltrations with aspermatogenesis in association with immune deposits along the excurrent duct normally occur in subhuman primates, and that these changes increase in incidence after vasectomy. Although the testicular disease highly resembles allergic orchitis, an immunologic basis remains to be established.
对25只长期输精管结扎的猴子和13只年龄匹配的对照动物的睾丸和肾脏的免疫病理学发现进行了比较。在60%的输精管结扎猴子的血清样本中发现了抗精子抗体，而对照动物的样本中未发现。在92%的输精管结扎动物和23%的对照动物中发现了睾丸炎、无精子症或两者兼有，类似于过敏性睾丸炎。附睾炎和附睾肉芽肿仅发生在输精管结扎动物中（52%）。通过免疫荧光法，在45%的对照猴子的输出小管和附睾头的基膜中检测到IgA、IgG和/或C3的颗粒状沉积。在输精管结扎动物中，免疫沉积物的发生率增加到91%，并且沉积物分布更广泛。尽管输精管结扎动物和对照动物在肾小球系膜区域都有IgM、IgG或两者兼有，但仅在输精管结扎猴子中发现了C3（29%）。本研究结果表明，在非人灵长类动物中，通常会出现单核细胞浸润伴无精子症以及输出管沿线的免疫沉积物，并且这些变化在输精管结扎后发生率增加。尽管睾丸疾病与过敏性睾丸炎非常相似，但免疫基础仍有待确立。
